Endocrine Abstracts

The Royal College of Physicians (RCP) published a report called Referring Wisely in June 2017. The report asked specialty physicians for a short list of conditions they felt would benefit from specialist input in the context of acute inpatient management (recommended referrals). It also asked for a list of conditions which need not be referred (avoid referrals).Methods: We retrospectively audited inpatient referrals from our electronic inpatient referral...

The Royal College of Physicians (RCP) published a report called Referring Wisely in June 2017. The report asked specialty physicians for a short list of conditions they felt would benefit from specialist input in the context of acute inpatient management (recommended referrals). It also asked for a list of conditions which need not be referred (avoid referrals).Methods: We retrospectively audited inpatient referrals from our electronic inpatient referral...

Rationale/Objective: Diabetes Mellitus (DM) and Interstitial lung Disease (ILD) share common pathogenetic pathways involving inflammatory cells and in particular monocytes and macrophages. Diabetic patients are at higher risk of developing pulmonary fibrosis, whereas DM is a major comorbidity in ILD patients. In our study, we analyzed retrospectively patients with ILD and aimed to examine differential characteristics between patients with and without DM, including disease para...

The Hippo kinase cascade is a crucial signalling pathway regulating organ growth during development in numerous organs. There is mounting evidence implicating this signalling pathway in tumour formation, where it is emerging as an anti-cancer target due to effective pharmacological inhibition of its transcriptional activators YAP/TAZ. We previously demonstrated activity of the Hippo kinase cascade in the mouse pituitary and nuclear association of YAP/TAZ with SOX2 expressing p...

Pituitary stem cells (PSCs) expressing SOX2 persist throughout life, giving rise to all pituitary endocrine lineages. These cells are highly active at early postnatal stages but this potential declines with age, rendering them mostly inactive in adulthood. The LATS/YAP/TAZ signaling cascade can influence stem cell fate and activity in multiple tissues and we previously identified activity of this axis in the developing and postnatal pituitary. Using a series of genetic manipul...

Background: Lack of expression of MGMT (O-6-methylguanine-DNA methyltransferase) is associated with a better tumour response to temozolomide. There are no systematic studies of MGMT expression in pituitary tumour series.Aim: We introduced MGMT immunohistochemistry for all pituitary adenoma specimens in 2011. In this study we investigated the immunohistochemical expression of MGMT in a large series of pituitary adenomas, in order to determine (1) the over...

IntroductionAlemtuzumab is an anti-CD52 antibody, leading to lysis and transient depletion of T and B lymphocytes. Its therapeutic effect is mediated by the alteration in immune repertoire that accompanies subsequent lymphocyte reconstitution. It is mainly used for the treatment of relapsing–remitting multiple sclerosis (RRMS). Common side effects are autoimmune diseases, including thyroid disease (>40%), immune thrombocytopenia (IT...

Background: Diabetic ketoacidosis (DKA) has been associated with severe hemolysis in patients with Glucose-6-phosphate dehydrogenase (G6PD) deficiency after restoration of euglycemia. Less than 30 cases have been reported so far. The exact mechanism is not fully understood.Case presentation: A 35-year-old African American man presented to the emergency department with polyuria, polydipsia, abdominal pain and weight loss the last 15 days. Physical examina...

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease with multisystem involvement and varied presentation but its association with adrenal insufficiency is rarely reported.Case presentation: A 30-year-old female presented to the emergency department with fever, lethargy and syncopal episodes during the last 48 h. She complained of general weakness, abdominal pain, nausea, vomiting, weight loss and anorexia for five months. Symptoms det...

Aim: To explore the epidemiological characteristics and symptoms of psychological distress of well-controlled endocrine patients without a diagnosis of a psychiatric disorder attending the Endocrine outpatient clinic of the University Hospital, Heraklion, Crete, Greece during the COVID-19 pandemic. Methods: Eighty-four patients participated by completing questionnaires about demographics, endocrine diagnosis, covid infection, preventive measures, vaccination s...